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Jacques Robert ABC Transporters and Multidrug Resistance


A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

11998.84 РУБ

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Guofeng You Drug Transporters. Molecular Characterization and Role in Disposition


This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters • Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery • Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials • Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers

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Gerd Folkers Transporters as Drug Targets


As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.

15372.6 РУБ

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Mohammed Khalid A.A. Pumps, Channels and Transporters. Methods of Functional Analysis


Describes experimental methods for investigating the function of pumps, channels and transporters Covers new emerging analytical methods used to study ion transport membrane proteins such as single-molecule spectroscopy Details a wide range of electrophysiological techniques and spectroscopic methods used to analyze the function of ion channels, ion pumps and transporters Covers state-of-the art analytical methods to study ion pumps, channels, and transporters, and where analytical chemistry can make further contributions

9373.54 РУБ

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Toshihisa Ishikawa Pharmacogenomics of Human Drug Transporters. Clinical Impacts


Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patients genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individuals genome affects those processes. The books eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug–drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.

11998.84 РУБ

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Ludman Harold S. ABC of Ear, Nose and Throat


This new edition of the best-selling ABC of Otolaryngology offers an up-to-date overview of otolaryngology, and head and neck surgery (ENT). Now in its fifth edition, the ABC of Ear, Nose and Throat advises on how best to manage patients with the most common ENT-related problems. Thoroughly revised and updated, this new edition includes extra chapters on facial pain, head and neck tumours, sleep apnoea and epistaxis, as well as recent advances in ENT evaluation and investigations (especially CT and MRI) and minimally invasive techniques. New material on voice, breathing and swallowing disorders, hearing impairment and cochlear implants has been added, with new pictures, illustrations and algorithms throughout. The ABC of Ear, Nose and Throat offers an essential introduction to this fundamental speciality for students, whilst providing a practical reference for GPs, GP registrars, junior doctors and nurses.

4896.95 РУБ

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Smithson W. Henry ABC of Epilepsy


ABC of Epilepsy provides a practical guide for general practitioners, and all those working in primary care, on the diagnosis, treatment and management of epilepsy, and for the continued monitoring and long term support of what is still a relatively poorly understood neurological disorder. This brand new title in the ABC series is highly illustrated throughout and presents what epilepsy is, its classification, and how to diagnose it. It covers anti-epileptic drugs and non-drug treatments, as well as self-management and living with epilepsy. Edited by a general practitioner and neurologist team, the ABC of Epilepsy reflects current NICE guidelines and is ideal for all GPs, primary health care professionals, practice nurses and specialist nurses, and non-specialist medical staff who play an increasing role in monitoring and managing of epilepsy patients.

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Jones Eileen Progress with Oxford: abc. Age 3-4


Progress with Oxford: abc Age 3-4 builds alphabet skills while helping your child to work independently. Engaging activities, fun characters and stickers keep them motivated and a progress chart captures achievements. Additional activities and support on oxfordowl.co.uk help your child to make progress in knowing their abc whilst having fun.

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Bernard Valman ABC of One to Seven


The ABC of One to Seven is a practical guide to the management of common physical and emotional problems of early childhood. New chapters include the prevention and management of obesity, behavioural and emotional problems, ADHD, autism, the child with fever, and changes in access to medical and social services. Including the latest NICE guidelines and advice on when to refer and how to manage the problem afterwards, each chapter provides relevant websites and resources for health workers. The ABC of One to Seven and the companion book, ABC of the First Year, have become standard guides for general practitioners, trainee doctors, medical students, midwives, nurses and health visitors. They are indispensible reference books for family doctor surgeries, emergency and outpatient departments, wards and libraries.

4585.78 РУБ

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Burns Robert The Complete Poems and Songs of


Издание полностью на английском языке.

301 РУБ

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RobediKappa.net è il portale dei negozi monomarca con insegna “Robe di Kappa”, lo storico marchio di abbigliamento casual sportivo per l'uomo e donna.

La Petite Robe Noire Légère от Guerlain Parfum - купить женские ...

Заказывайте La Petite Robe Noire Légère в интернет-магазине Aroma-Butik.ru. У нас указана актуальная цена, наличие и отзывы покупателей. Удобные ...

«Robe di Kappa Athletic Shorts» — Клуб FURFUR

tomall.ru → Каталоги → Каталог сети магазинов metro в Москве → Трусы и боксеры мужские ROBE DI KAPPA в ассортименте. Трусы и боксеры мужские ROBE DI KAPPA в ассортименте. Гипермаркет: metro. ... Товар Трусы и боксеры мужские ROBE DI KAPPA в ассортименте Вы можете закупить в гипермаркете metro по лучшей цене в период действия скидки с 28-11-2013 по 11-12-2013.

Robe-Di-Kappa-Banda-Track-Bottoms-in-Black-retro-taping...

Robe-Di-Kappa-Banda-Track-Bottoms-in-Black-retro-taping-90s-track-pants. Find this Pin and more on Women's fashion by Berenice Salas. Tags. ... Kappa Clothing, Football Images, Soccer Shirts, Print Advertising, Vintage Advertisements, Ads, Fashion Forms, Sports Brands, Archive, Display, Poster, Football T Shirts, Soccer Pictures, Vintage Ads, Print Ads. Frank Mondano. Advertising. @kappa_culture on Instagram: “@lilianafrvncisco 🔥”.

Трусы ROBE DI KAPPA

Трусы ROBE DI KAPPA. Краткое описание бренда:Бренд Robe di Kappa принадлежит крупному итальянскому производителю. Марка производит качественное мужское белье из натуральных материалов. Целевая аудитория бренда - динамичные современные люди, которые предпочитают неформальный стиль в любых обстоятельствах, ценят в вещах удобство и высокое качество и готовы за это платить.

Robe di Kappa - Fashion - Via delle Convertite 10, Rome, Roma, Italy ...

Robe di Kappa in Rome, reviews by real people. Yelp is a fun and easy way to find, recommend and talk about what's great and not so great in Rome and ...

Одежда для бизнес woman – Утонченная классика

Robe di Kappa. For other uses, see Kappa (disambiguation). This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages). This article's lead section does not adequately summarize key points of its contents. Please consider expanding the lead to provide an accessible overview of all important aspects of the article. Please discuss this issue on the article's talk page.